肖邦，博士，讲师

  邮箱：xiaob@qau.edu.cn
个人履历：

  2012.9-2016.6，华南农业大学，农学学士

  2016.9-2019.6，中山大学，理学硕士

  2019.9-2023.6，中山大学，理学博士

  2023.8-2025.8，中山大学，博士后

  2025.9-至今，青岛农业大学，讲师

研究方向：

 对虾先天免疫及病害防控方向：（1）WSSV/DIV1/高致病副溶血弧菌的致病机制及与对虾宿主互作研究；（2）温度诱导的热休克蛋白在高温下抗病毒机制；（3）高致病副溶血弧菌毒力蛋白PirAB致病机制研究。

 科研成果：

 主持山东省自然科学基金项目（C类）、广东省自然科学基金青年项目和中国博士后科学基金项目等3项。以第一作者或通讯作者（含共同）在PLoS Pathogens、eLife、Journal of Immunology、Journal of Virology 及Emerging Microbes & Infections等领域期刊发表论文11篇，授权国家发明专利1项。

 代表成果：

 1.B. Xiao, Q. Fu, S. Niu, P. Zhu, J. He, C. Li, Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry, Emerging Microbes and Infections 9(1) (2020) 390-412.
 2.B. Xiao, X. Liao, H. Wang, J. He, C. Li, BigPEN, an antimicrobial peptide of penaeidin family from shrimp Litopenaeus vannamei with membrane permeable and DNA binding activity, Fish Shellfish Immunol Rep 2 (2021) 100034.
 3.B. Xiao, Y. Wang, D. Xian, T. Fan, J. He, C. Li, Identification of a Double-β-Defensin with Multiple Antimicrobial Activities in a Marine Invertebrate, Journal of Immunology 210(9) (2023) 1324-1337.
 4.B. Xiao, Y. Wang, J. He, C. Li, Febrile Temperature Acts through HSP70-Toll4 Signaling to Improve Shrimp Resistance to White Spot Syndrome Virus, J Immunol 213(8) (2024) 1187-1201.
 5.B. Xiao, D. Hou, J. Pan, F. Kang, Y. Wang, J. He, C. Li, Heat shock protein 70 (HSP70) regulates innate immunity and intestinal microbial homeostasis against Vibrio parahaemolyticus in shrimp, Aquaculture 596 (2025) 741814.
 6.B. Xiao, J. Pan, F. Zheng, F. Kang, Y. Wang, J. He, C. Li, Identification and functional characterization of a novel transmembrane protein LvLRRm1 containing leucine-rich repeats in shrimp Litopenaeus vannamei, Fish & Shellfish Immunology 165 (2025) 110507.
 7.B. Xiao, F. Kang, Q. Li, J. Pan, Y. Wang, J. He, C. Li, White spot syndrome virus immediate-early protein (wsv100) antagonizes the NF-kappaB pathway to inhibit innate immune response in shrimp, PLoS Pathog 21(6) (2025) e1012828.
 8.B. Xiao#, F. Kang#, T. Fan, Q. Li, M. Liu, J. Pan, J. He, C. Li, Single-cell RNA sequencing reveals hemocyte heterogeneity, differentiation trajectories, and viral tropism in shrimp (Macrobrachium rosenbergii) infected with decapodiridovirus litopenaeus1, J Virol 99(8) (2025) e0079025.
 9.F. Kang#, B. Xiao#, T. Fan, Q. Li, M. Liu, J. He, C. Li, Subpopulation-specific apoptotic responses of hemocytes to decapod iridescent virus 1 in Macrobrachium rosenbergii, Fish & Shellfish Immunology 167 (2025) 110685.
 10.B. Xiao, S. Chen, Y. Wang, X. Liao, J. He, C. Li, Heat Shock Factor regulation of antimicrobial peptides expression suggests a conserved defense mechanism induced by febrile temperature in arthropods, eLife 13 (2026) RP101460.
 11.B. Xiao#, Y. Wang#, F. Kang#, S. Niu, J. He, Z. Zhu, C. Li, Integrin α6 functions as an immune recognition receptor for PirABvp and activates MAPK signaling to restrict acute hepatopancreatic necrosis disease in shrimp, International Journal of Biological Macromolecules 369 (2026) 152814.